

## Known Blind Spots (updated 2026-03-31)
- **DATASET PROVENANCE CRISIS (2026-03-31)**: ALL 12 PMIDs in extracted_cytokines.csv are incorrect (possible LLM hallucination). Dataset rebuild in progress (#1709). NO analysis results are trustworthy until rebuild complete.
- **Th2 axis unmeasured**: No PANDAS/PANS studies in our dataset measured IL-4 or IL-13. Literature search (#1431) confirmed gap.
- **IPD unavailable**: All data is study-level aggregated. Prediction model confirmed as artifact (AUC=1.0). IPD needed before prediction modeling.
- **CIRS/complement unvalidated**: C4a, C3, MMP-9 network module is theoretical. Literature search (#1432) found sparse data.
- **Prediction model artifact**: AUC=1.0 from study-level aggregation. Do NOT include until IPD obtained.

## Cross-Analyte Ranking Correction (2026-03-27)
- IL-1b vs IL-6 pooled ranking is a COMPOSITION ARTIFACT. Within-study data shows IL-6 > IL-1b in 3/3 shared studies. NOTE: These findings are on UNVERIFIED data — must be re-evaluated after rebuild.

## Code Validation Status (still valid)
- Immune axis classification: validated (#1361 done)
- Treatment response analysis: validated (#1363 done)
- Within-study comparison code: validated (#1494 — code correct, cancelled due to data issue)
- Meta-analysis engine: code logic sound
- Network construction: code logic sound (IFNg two-compartment + IL-12 fixes applied)
