======================================================================
NF1-Loss Dependency Atlas - Phase 3b: TP53-Stratified Analysis
======================================================================

TP53-mutant stratum: 52 NF1-lost vs 376 NF1-intact
TP53-WT stratum: 15 NF1-lost vs 209 NF1-intact

NF1-specific (confirmed): 0 genes
TP53-confounded: 1 genes
NF1-specific (TP53-masked): 0 genes

CONFOUND-PRONE GENE SETS
------------------------------------------------------------

  DDR:
    CHEK1: d_unstrat=-0.241, d_tp53mut=-0.197 => not significant
    WEE1: d_unstrat=-0.051, d_tp53mut=-0.123 => not significant
    ATR: d_unstrat=-0.025, d_tp53mut=0.002 => not significant
    PARP1: d_unstrat=0.127, d_tp53mut=0.096 => not significant

  Cell cycle:
    CDK2: d_unstrat=-0.150, d_tp53mut=-0.086 => not significant
    CDK6: d_unstrat=-0.125, d_tp53mut=-0.106 => not significant
    RB1: d_unstrat=-0.073, d_tp53mut=-0.123 => not significant
    CCND1: d_unstrat=0.023, d_tp53mut=0.015 => not significant
    CDK4: d_unstrat=0.077, d_tp53mut=0.054 => not significant

  Epigenetic/PRC2:
    SUZ12: d_unstrat=-0.002, d_tp53mut=-0.049 => not significant
    DOT1L: d_unstrat=0.097, d_tp53mut=0.079 => not significant
    EED: d_unstrat=0.101, d_tp53mut=-0.008 => not significant
    BRD4: d_unstrat=0.107, d_tp53mut=0.300 => not significant
    EZH2: d_unstrat=0.115, d_tp53mut=0.065 => not significant

TP53-CONFOUNDED HITS (unstratified sig, stratified not sig)
------------------------------------------------------------
  RIT1: d_unstrat=-0.646, d_tp53mut=-0.631
