gene,full_name,category,mechanism,neurodegeneration_link,de_score,de_padj,regulated_by_activity_tf,double_hit
NOS1,Neuronal nitric oxide synthase,Nitrosative/oxidative stress,"Produces NO causing mitochondrial Complex I inhibition, protein S-nitrosylation, DNA damage","Implicated in Parkinson's, Huntington's; excess NO drives nitrosative stress",18.33,5.45e-72,FOS,True
UCHL1,Ubiquitin C-terminal hydrolase L1,Ubiquitin-proteasome / proteostasis,Ubiquitin recycling enzyme; dysfunction impairs protein degradation capacity,PARK5 locus in Parkinson's disease; loss-of-function → protein aggregate accumulation,12.26,4.5e-32,,False
PRNP,Prion protein (cellular),Protein aggregation / misfolding,Cellular prion protein; misfolding triggers prion-like pathology; also copper homeostasis,Prion diseases; high SST neuron expression is established; misfolding → proteotoxic cascades,10.91,2.14e-25,,False
GRIA3,Glutamate ionotropic receptor AMPA type subunit 3,Excitotoxicity,AMPA receptor subunit; excess glutamatergic input → calcium overload → excitotoxic death,Excitotoxicity is a core neurodegeneration mechanism; AMPA overactivation in ischemia/neurodegeneration,10.36,6.42e-23,,False
CALM2,Calmodulin 2,Calcium signaling dysregulation,Universal calcium sensor; high expression → amplified calcium-dependent signaling cascades,"Calcium overload triggers mitochondrial permeability transition, calpain activation, apoptosis",9.57,1.42e-19,,False
CHRM3,Muscarinic acetylcholine receptor M3,Calcium signaling dysregulation,Gq-coupled receptor → IP3 → ER calcium release; amplifies intracellular calcium transients,Cholinergic-calcium axis; M3 activation can exacerbate calcium-mediated toxicity,9.46,3.98e-19,,False
