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WRN-MSI Pan-Cancer Atlas — Phase 2: WRN Effect Sizes
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WRN DEPENDENCY (MSI-H vs MSS)
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  Uterus: d=-1.086 [-2.056, -0.250] FDR=4.950e-02 perm_p=0.0125 LOO=robust → ROBUST
  Bowel: d=-2.844 [-5.290, -1.760] FDR=1.115e-06 perm_p=0.0001 LOO=robust → ROBUST
  Pan-cancer (pooled): d=-2.833 [-3.765, -2.028] FDR=1.379e-11 perm_p=0.0001 LOO=robust → ROBUST

WRNIP1 DEPENDENCY (MSI-H vs MSS)
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  Uterus: d=0.218 [-0.704, 1.175] FDR=7.862e-01 perm_p=0.5939 LOO=robust → NOT_SIGNIFICANT
  Bowel: d=0.052 [-0.490, 0.626] FDR=7.862e-01 perm_p=0.8672 LOO=robust → NOT_SIGNIFICANT
  Pan-cancer (pooled): d=0.073 [-0.168, 0.292] FDR=4.443e-01 perm_p=0.6389 LOO=robust → NOT_SIGNIFICANT

CONTROL HELICASES (expect NOT_SIGNIFICANT)
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  Uterus / BLM: d=-0.321 [-1.185, 0.586] FDR=9.208e-01 → NOT_SIGNIFICANT
  Uterus / RECQL: d=0.109 [-0.890, 0.959] FDR=9.208e-01 → NOT_SIGNIFICANT
  Bowel / BLM: d=-0.099 [-0.697, 0.468] FDR=9.208e-01 → NOT_SIGNIFICANT
  Bowel / RECQL: d=-0.487 [-1.134, 0.129] FDR=5.380e-01 → NOT_SIGNIFICANT
  Pan-cancer (pooled) / BLM: d=-0.103 [-0.393, 0.209] FDR=5.423e-01 → NOT_SIGNIFICANT
  Pan-cancer (pooled) / RECQL: d=-0.200 [-0.495, 0.068] FDR=5.423e-01 → NOT_SIGNIFICANT

INTERPRETATION
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  ROBUST WRN-MSI SL in 3 context(s):
    Uterus: d=-1.086
    Bowel: d=-2.844
    Pan-cancer (pooled): d=-2.833

TP53 STRATIFICATION (within MSI-H lines)
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  Clinical context: WRN SL may be p53/PUMA-dependent (PMID 36508676)
  TP53-mutant MSI tumors may partially resist WRN inhibitors

  Pan-cancer (pooled):
    TP53-WT: n=16, mean_WRN=-1.354, median_WRN=-1.446 d_vs_mut=-0.556 p=2.559e-02
    TP53-mutant: n=18, mean_WRN=-0.964, median_WRN=-0.302
    TP53-GOF-hotspot: n=10, mean_WRN=-0.505, median_WRN=-0.592

  CNS/Brain:
    TP53-WT: n=1, mean_WRN=-0.115, median_WRN=-0.115

  Head and Neck:
    TP53-mutant: n=2, mean_WRN=-0.163, median_WRN=-0.163

  Lung:
    TP53-mutant: n=2, mean_WRN=-0.194, median_WRN=-0.194
    TP53-GOF-hotspot: n=1, mean_WRN=-0.078, median_WRN=-0.078

  Lymphoid:
    TP53-WT: n=1, mean_WRN=-0.594, median_WRN=-0.594
    TP53-mutant: n=1, mean_WRN=-0.038, median_WRN=-0.038
    TP53-GOF-hotspot: n=1, mean_WRN=0.031, median_WRN=0.031

  Breast:
    TP53-WT: n=1, mean_WRN=-0.539, median_WRN=-0.539
    TP53-mutant: n=1, mean_WRN=-0.248, median_WRN=-0.248

  Uterus:
    TP53-WT: n=3, mean_WRN=-0.739, median_WRN=-0.641
    TP53-mutant: n=2, mean_WRN=-2.658, median_WRN=-2.658
    TP53-GOF-hotspot: n=3, mean_WRN=-0.728, median_WRN=-0.666

  Ovary/Fallopian Tube:
    TP53-WT: n=1, mean_WRN=-1.632, median_WRN=-1.632
    TP53-mutant: n=1, mean_WRN=-1.446, median_WRN=-1.446
    TP53-GOF-hotspot: n=2, mean_WRN=-0.297, median_WRN=-0.297

  Esophagus/Stomach:
    TP53-WT: n=2, mean_WRN=-1.736, median_WRN=-1.736
    TP53-mutant: n=2, mean_WRN=-1.258, median_WRN=-1.258

  Bowel:
    TP53-WT: n=7, mean_WRN=-1.870, median_WRN=-2.001
    TP53-mutant: n=4, mean_WRN=-1.691, median_WRN=-1.653
    TP53-GOF-hotspot: n=1, mean_WRN=-0.984, median_WRN=-0.984

  Myeloid:
    TP53-mutant: n=1, mean_WRN=-0.034, median_WRN=-0.034

  Skin:
    TP53-mutant: n=1, mean_WRN=-0.059, median_WRN=-0.059
    TP53-GOF-hotspot: n=1, mean_WRN=-0.464, median_WRN=-0.464

  Cervix:
    TP53-GOF-hotspot: n=1, mean_WRN=-0.780, median_WRN=-0.780

  Vulva/Vagina:
    TP53-mutant: n=1, mean_WRN=-0.217, median_WRN=-0.217
